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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1984-1-7
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pubmed:abstractText |
Substance P induced a dose-dependent contraction of human segmental bronchi in vitro with a threshold dose of about 10(-6) M. These preparations were obtained from patients undergoing lung tumor surgery. The substance P-induced contractions were resistant to mepyramine and atropine, suggesting a direct effect on the bronchial smooth muscle. Capsaicin (10(-5) M) also induced a slowly developing strong atropine-resistant contraction of human bronchi in vitro. a rapid tachyphylaxis developed for the response to capsaicin. Both substance P and capsaicin were less potent than acetylcholine and histamine in inducing contractions of human bronchi. This finding may however be partly due to the experimental conditions and both substance P and capsaicin were comparatively much more potent in guinea-pig preparations. Transmural field stimulation of the bronchial preparations in man resulted in contractions that were largely sensitive to atropine. The presence of capsaicin-induced bronchial contractions however indicates the existence of a local non-cholinergic axon-reflex control of bronchial smooth muscle tone by substance P in man.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Acetylcholine,
http://linkedlifedata.com/resource/pubmed/chemical/Atropine,
http://linkedlifedata.com/resource/pubmed/chemical/Capsaicin,
http://linkedlifedata.com/resource/pubmed/chemical/Histamine,
http://linkedlifedata.com/resource/pubmed/chemical/Substance P,
http://linkedlifedata.com/resource/pubmed/chemical/Tetrodotoxin
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0001-6772
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
119
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
49-53
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:6196939-Acetylcholine,
pubmed-meshheading:6196939-Aged,
pubmed-meshheading:6196939-Animals,
pubmed-meshheading:6196939-Atropine,
pubmed-meshheading:6196939-Bronchi,
pubmed-meshheading:6196939-Capsaicin,
pubmed-meshheading:6196939-Dose-Response Relationship, Drug,
pubmed-meshheading:6196939-Guinea Pigs,
pubmed-meshheading:6196939-Histamine,
pubmed-meshheading:6196939-Humans,
pubmed-meshheading:6196939-Middle Aged,
pubmed-meshheading:6196939-Muscle, Smooth,
pubmed-meshheading:6196939-Muscle Contraction,
pubmed-meshheading:6196939-Substance P,
pubmed-meshheading:6196939-Tetrodotoxin
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pubmed:year |
1983
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pubmed:articleTitle |
Substance P and capsaicin-induced contraction of human bronchi.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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