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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
1983-11-23
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pubmed:abstractText |
Mouse strains carrying the kappa allele at loci A beta, A alpha, E beta, and E alpha are nonresponders to lactate dehydrogenase B (LDHB) and to allotypic determinants of IgG2a myeloma proteins (for example, UPC10 used in this study). The nonresponsiveness to these antigens is caused by T suppressor (Ts) cells that prevent antigen-primed T helper (Th) cells from proliferating. We demonstrate here that monoclonal antibodies specific for an A region-controlled molecule selectively expressed on T cells (A-T) are capable of inducing anti-LDHB and anti-UPC10 responses of primed T cells from nonresponder strains. A monoclonal anti-J antibody that cross-reacts with the A-T molecule also induces responsiveness, whereas another J-specific antibody that lacks this cross-reactivity fails to do so. The mechanism of response induction is blocking of the interaction between the Ts cell or its factor (TsF) and the target of suppression, the antigen-specific Lyt-1+2- (Th) cell. The blocking occurs at the level of the Ts cell and the TsF. The data indicate that Ts cells and TsF carry a unique, A region-controlled molecule that is not only functionally analogous but also serologically similar to the J molecule.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Monoclonal,
http://linkedlifedata.com/resource/pubmed/chemical/Epitopes,
http://linkedlifedata.com/resource/pubmed/chemical/L-Lactate Dehydrogenase,
http://linkedlifedata.com/resource/pubmed/chemical/Lymphokines,
http://linkedlifedata.com/resource/pubmed/chemical/Myeloma Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Suppressor Factors, Immunologic
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0022-1767
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
131
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1646-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:6194210-Animals,
pubmed-meshheading:6194210-Antibodies, Monoclonal,
pubmed-meshheading:6194210-Binding, Competitive,
pubmed-meshheading:6194210-Epitopes,
pubmed-meshheading:6194210-Female,
pubmed-meshheading:6194210-Genes, MHC Class II,
pubmed-meshheading:6194210-Immune Tolerance,
pubmed-meshheading:6194210-L-Lactate Dehydrogenase,
pubmed-meshheading:6194210-Lymphocyte Activation,
pubmed-meshheading:6194210-Lymphokines,
pubmed-meshheading:6194210-Male,
pubmed-meshheading:6194210-Mice,
pubmed-meshheading:6194210-Mice, Inbred Strains,
pubmed-meshheading:6194210-Myeloma Proteins,
pubmed-meshheading:6194210-Suppressor Factors, Immunologic,
pubmed-meshheading:6194210-T-Lymphocytes,
pubmed-meshheading:6194210-T-Lymphocytes, Regulatory
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pubmed:year |
1983
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pubmed:articleTitle |
Induction of T cell responses in nonresponder mice by abolishing suppression with monoclonal antibodies recognizing A region-controlled, T cell-specific determinants.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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