| pubmed-article:6193527 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6193527 | lifeskim:mentions | umls-concept:C0012854 | lld:lifeskim |
| pubmed-article:6193527 | lifeskim:mentions | umls-concept:C0282056 | lld:lifeskim |
| pubmed-article:6193527 | lifeskim:mentions | umls-concept:C0037791 | lld:lifeskim |
| pubmed-article:6193527 | lifeskim:mentions | umls-concept:C0205344 | lld:lifeskim |
| pubmed-article:6193527 | lifeskim:mentions | umls-concept:C1880371 | lld:lifeskim |
| pubmed-article:6193527 | lifeskim:mentions | umls-concept:C0591833 | lld:lifeskim |
| pubmed-article:6193527 | pubmed:issue | 19 | lld:pubmed |
| pubmed-article:6193527 | pubmed:dateCreated | 1983-10-28 | lld:pubmed |
| pubmed-article:6193527 | pubmed:abstractText | The clonal heterogeneity of nine monoclonal antibodies with absolute specificities for deoxyribonucleic acid (DNA) was analyzed. These monoclonal anti-DNA antibodies were generated in three different fusion experiments using autoimmune (NZB X NZW)F1 mouse spleen cells. Isoelectric focusing analyses demonstrated different isoelectric points within the IgG2a and IgG2b subclasses. Three anti-idiotypic antisera were prepared (one in a rabbit and two in mice) against two monoclonal anti-DNA antibodies. These antisera detected idiotypic determinants uniquely associated with homologous hybridoma anti-DNA antibodies. Two of these idiotypes could be detected at low levels in the sera of (NZB X NZW)F1 mice. Anti-PME77 idiotypic antiserum had no effect in vitro on the total binding capacity of (NZB X NZW)F1 sera. Taken together these results demonstrate that, in (NZB X NZW)F1 mice, the anti-DNA antibody repertoire contains molecules that show similar antigen binding characteristics but are not structurally uniform. | lld:pubmed |
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| pubmed-article:6193527 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6193527 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6193527 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:6193527 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6193527 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:6193527 | pubmed:issn | 0027-8424 | lld:pubmed |
| pubmed-article:6193527 | pubmed:author | pubmed-author:CAMPH MHM | lld:pubmed |
| pubmed-article:6193527 | pubmed:author | pubmed-author:TropDD | lld:pubmed |
| pubmed-article:6193527 | pubmed:author | pubmed-author:JacobLL | lld:pubmed |
| pubmed-article:6193527 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6193527 | pubmed:volume | 80 | lld:pubmed |
| pubmed-article:6193527 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6193527 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6193527 | pubmed:pagination | 6024-7 | lld:pubmed |
| pubmed-article:6193527 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:6193527 | pubmed:meshHeading | pubmed-meshheading:6193527-... | lld:pubmed |
| pubmed-article:6193527 | pubmed:year | 1983 | lld:pubmed |
| pubmed-article:6193527 | pubmed:articleTitle | Murine monoclonal anti-DNA antibodies with an absolute specificity for DNA have a large amount of idiotypic diversity. | lld:pubmed |
| pubmed-article:6193527 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6193527 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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