Linked Life Data

6193354

Source:http://linkedlifedata.com/resource/pubmed/id/6193354

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1983-10-8
pubmed:abstractText
In the isolated perfused hindquarters of rats pretreated with reserpine, vasoconstrictor responses were induced by activation of postjunctional alpha 1- and alpha 2-adrenoceptors. B-HT 920 and methoxamine were used as selective stimulants of alpha 2- and alpha 1-adrenoceptors, respectively. Prazosin (pA2 8.83) exhibited a competitive antagonism toward methoxamine-induced vasoconstrictor responses, whereas yohimbine (pA2 8.95) effectively antagonized B-HT 920-induced vasoconstriction in a competitive manner. When calcium was omitted from the perfusion fluid, no vasoconstriction via alpha 2-adrenoceptors could be evoked. On the other hand, raising the extracellular calcium concentration in the perfusion fluid enhanced the alpha 2-adrenoceptor-mediated vasoconstrictor effects. Vasoconstriction via postjunctional alpha 1-adrenoceptors seemed hardly, if at all, dependent on extracellular calcium. The calcium entry blockers Co2+, La3+, and nisoldipine selectively inhibited the alpha 2-adrenoceptor-induced vasoconstriction in a noncompetitive manner. The results further support the concept that extracellular calcium is a prerequisite for the process of vasoconstriction induced by activation of postjunctional alpha 2-adrenoceptors.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0160-2446
pubmed:author
pubmed:issnType
Print
pubmed:volume
5
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
580-5
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
alpha 1- and alpha 2-adrenoceptor stimulation in the isolated perfused hindquarters of the rat: an in vitro model.
pubmed:publicationType
Journal Article, In Vitro