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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1983-10-8
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pubmed:abstractText |
The interaction between cloned amplifier T cells and stimulating cells has been probed with the use of a monoclonal antibody selected for its ability to inhibit stimulation of Mls- and la-reactive T cells. The antibody recognizes a public determinant on I-A- and I-E-coded molecules of a variety of murine H-2 haplotypes. The antibody inhibits the proliferation of the I-Ab-reactive T cell clone 48.1 and of the Mls-reactive T cell clones L2 and Fa 13. The antibody may be added as late as 3 hr after initiation of culture to cause inhibition of L2 proliferation and release of interleukin 2. A profound inhibition of primary and secondary mixed leukocyte responses also is observed. The results indicate that a large fraction of Mls reactive T cells require interaction with la antigens.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0022-1767
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
131
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1056-64
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:6193171-Animals,
pubmed-meshheading:6193171-Antibodies, Monoclonal,
pubmed-meshheading:6193171-Antigen-Antibody Reactions,
pubmed-meshheading:6193171-Binding, Competitive,
pubmed-meshheading:6193171-Binding Sites, Antibody,
pubmed-meshheading:6193171-Clone Cells,
pubmed-meshheading:6193171-Cytotoxicity, Immunologic,
pubmed-meshheading:6193171-Epitopes,
pubmed-meshheading:6193171-Genes, MHC Class II,
pubmed-meshheading:6193171-H-2 Antigens,
pubmed-meshheading:6193171-Histocompatibility Antigens,
pubmed-meshheading:6193171-Histocompatibility Antigens Class II,
pubmed-meshheading:6193171-Interleukin-2,
pubmed-meshheading:6193171-Lymphocyte Activation,
pubmed-meshheading:6193171-Mice,
pubmed-meshheading:6193171-Mice, Inbred C57BL,
pubmed-meshheading:6193171-Mice, Inbred DBA,
pubmed-meshheading:6193171-Rats,
pubmed-meshheading:6193171-Rats, Inbred Lew,
pubmed-meshheading:6193171-T-Lymphocytes
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pubmed:year |
1983
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pubmed:articleTitle |
Inhibition of proliferation of MIs- and Ia-reactive cloned T cells by a monoclonal antibody against a determinant shared by I-A and I-E.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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