Linked Life Data

6192031

Source:http://linkedlifedata.com/resource/pubmed/id/6192031

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1983-9-23
pubmed:abstractText
Mutagenicity of extracts of particles collected from the exhaust of six different European and American diesel cars was evaluated in Salmonella strains TA 1535, TA 100, TA 1537, TA 1538 and TA 98. The extracts demonstrated direct, dose-related mutagenicity in all strains except TA 1535, with the potencies varying from 6-17 revertants/micrograms in TA 100, the most sensitive strain. Addition of Aroclor 1254 induced rat liver homogenate fractions decreased the direct response in TA 100 and increased the response in four of the six extracts in TA 98. Differences in the extractable organic fraction of the particles and the particulate emission rates for the six cars had a greater influence on the amount of mutagenicity emitted (revertants per mile) than the actual mutagenic potency of the organics. The ranking of the cars by revertants/mile was different than ranking by revertants/micrograms extractable organics. The response of two of the six extracts in a nitroreductase deficient strain of Salmonella (TA 100 FR1) were significantly lower than the response in TA 100, suggesting that reduction of nitroaromatics by bacterial enzymes may be influential in the direct response. Results of testing triplicate samples collected in three different cars demonstrated good repeatability in sampling and bioassay procedures.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0272-0590
pubmed:author
pubmed:issnType
Print
pubmed:volume
1
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
260-5
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:articleTitle
Mutagenicity of diesel exhaust particle extracts: influence of car type.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S.