Linked Life Data

6191126

Source:http://linkedlifedata.com/resource/pubmed/id/6191126

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1983-8-11
pubmed:abstractText
A series of oestrogens and anti-oestrogens have been compared with respect to their effects on RNA synthesis in the uterus of immature rats. The normal transcriptional response to oestrogen is a biphasic stimulation of transcription. The first phase is a sharp stimulation of RNA synthesis, 2-4 h after hormone administration which peaks at 7-11-fold unstimulated controls but which rapidly falls to near control levels by 8 h after injection. The second phase is a broad peak of RNA synthesis, typically lasting from 12-32 h after hormone administration and accompanied to a much greater extent than the first phase by increases in precursor pool sizes. Oestradiol-17 beta does not show the second phase of this response. This is presumably due to rapid metabolism as derivatives with a longer tissue half life induce the complete response. The first phase of the response is not induced by tamoxifen but is by monohydroxy tamoxifen.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0022-4731
pubmed:author
pubmed:issnType
Print
pubmed:volume
18
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
7-11
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1983
pubmed:articleTitle
A rationalization of the effects of anti-oestrogens and oestrogens on uterine RNA synthesis in the immature rat.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't