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rdf:type |
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lifeskim:mentions |
umls-concept:C0001699,
umls-concept:C0004561,
umls-concept:C0005767,
umls-concept:C0007634,
umls-concept:C0086418,
umls-concept:C0205250,
umls-concept:C0205431,
umls-concept:C0332152,
umls-concept:C0332461,
umls-concept:C1514485,
umls-concept:C1998793
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pubmed:issue |
2
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pubmed:dateCreated |
1983-8-17
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pubmed:abstractText |
The plaque forming cell (PFC) and proliferative responses of human peripheral blood lymphocytes and highly purified blood B cells induced by pokeweed mitogen (PWM) and group A streptoccocal cell membranes (A-ScM) were compared with the responses triggered by various cell preparations of Klebsiella pneumoniae K 43 (Klebs). The number of PFC was determined by a protein A plaque assay, and lymphoproliferation was measured by 3H-thymidine incorporation. In cell cultures stimulated with PWM and A-ScM, lymphocyte proliferation appeared to be associated with the generation of PFC. Klebs caused development of PFC without measurable prior proliferation. Whereas the response to PWM and A-ScM was absolutely T cell-dependent, highly purified B cells generated PFC when incubated with Klebs. Moreover, restitution of T cells to the B cell fraction did not augment (or diminish) the number of plaques. These studies establish that Klebs cell envelope structures contain a T cell-independent polyclonal B cell activator for human B lymphocytes in a high stage of differentiation. Use of this probe should provide further insight into the cellular interactions involved in the differentiation of antibody forming cells in humans.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6190601-1081068,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6190601-1094629,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6190601-14858403,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6190601-224538,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6190601-309629,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6190601-315990,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6190601-369751,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6190601-382482,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6190601-389443,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6190601-4606790,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6190601-6258810,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6190601-6454516,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6190601-6966649,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6190601-6972434,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6190601-6972811,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6190601-6977576,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6190601-6980749,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6190601-6995307,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6190601-7002234,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6190601-701481,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6190601-7033287,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6190601-7035395,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6190601-7195065,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6190601-7381924,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6190601-789096,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6190601-89732
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0009-9104
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
52
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
372-80
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:6190601-B-Lymphocytes,
pubmed-meshheading:6190601-Cell Division,
pubmed-meshheading:6190601-Cell Membrane,
pubmed-meshheading:6190601-Cells, Cultured,
pubmed-meshheading:6190601-Hemolytic Plaque Technique,
pubmed-meshheading:6190601-Humans,
pubmed-meshheading:6190601-Klebsiella pneumoniae,
pubmed-meshheading:6190601-Lymphocyte Activation,
pubmed-meshheading:6190601-Lymphocyte Cooperation,
pubmed-meshheading:6190601-Staphylococcal Protein A,
pubmed-meshheading:6190601-Staphylococcus,
pubmed-meshheading:6190601-Thymidine,
pubmed-meshheading:6190601-Time Factors,
pubmed-meshheading:6190601-alpha-Macroglobulins
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pubmed:year |
1983
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pubmed:articleTitle |
Klebsiella pneumoniae stimulate highly purified human blood B cells to mature into plaque forming cells without prior proliferation.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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