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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1983-7-8
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pubmed:abstractText |
1. The offspring (F1) of a parent generation (P) were mated on a brother-to-sister system to produce a second generation (F2), which was then mated in the same way to produce a third generation (F3). 2. Each of these generations were divided into two groups, controls and treated. 3. A single dose of 100 mg/kg of semicarbazide was administered to the treated Wistar rats on the 10th day of their pregnancy. 4. DNA, RNA and protein hepatic levels were measured in the livers of either 21-day-old foetuses or 1, 7, 15 or 30-day-old offspring. 5. These levels were also studied in the pregnant rats on day 21 of gestation. 6. Semicarbazide produced a significant decrease of these levels not only in the foetuses, offspring and pregnant rats but also in the controls, F2 and F3, from treated P and F1 respectively.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
0742-8413
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
74
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
447-50
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pubmed:dateRevised |
2007-7-23
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pubmed:meshHeading |
pubmed-meshheading:6189671-Animals,
pubmed-meshheading:6189671-DNA,
pubmed-meshheading:6189671-Female,
pubmed-meshheading:6189671-Liver,
pubmed-meshheading:6189671-Male,
pubmed-meshheading:6189671-Pregnancy,
pubmed-meshheading:6189671-Prenatal Exposure Delayed Effects,
pubmed-meshheading:6189671-Proteins,
pubmed-meshheading:6189671-RNA,
pubmed-meshheading:6189671-Rats,
pubmed-meshheading:6189671-Rats, Inbred Strains,
pubmed-meshheading:6189671-Semicarbazides
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pubmed:year |
1983
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pubmed:articleTitle |
Effects of semicarbazide on DNA, RNA and protein hepatic levels on four subsequent generations of Wistar rats.
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pubmed:publicationType |
Journal Article
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