rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
4
|
pubmed:dateCreated |
1983-7-8
|
pubmed:abstractText |
The effects of two chemotherapeutic regimens, peplomycin (PLM) plus carbazilquinone and PLM plus mitomycin, on non-small cell carcinoma of the lung were evaluated by a randomized controlled trial. Seven partial responses were observed in 53 evaluable patients, for an overall response rate of 13.2%. There was no difference in response rate or in median survival time between PLM plus carbazilquinone (11.5% and 32 weeks) and PLM plus mitomycin (14.8% and 25 weeks). Seven patients developed interstitial pneumonitis, and four died of pulmonary fibrosis. It was concluded that the chemotherapeutic regimens that include PLM are only marginally effective against non-small cell carcinoma of the lung, with relatively frequent pulmonary fibrosis.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Apr
|
pubmed:issn |
0361-5960
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
67
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
385-7
|
pubmed:dateRevised |
2007-11-15
|
pubmed:meshHeading |
pubmed-meshheading:6189601-Adenocarcinoma,
pubmed-meshheading:6189601-Adult,
pubmed-meshheading:6189601-Aged,
pubmed-meshheading:6189601-Antibiotics, Antineoplastic,
pubmed-meshheading:6189601-Azirines,
pubmed-meshheading:6189601-Bleomycin,
pubmed-meshheading:6189601-Carbazilquinone,
pubmed-meshheading:6189601-Carcinoma, Small Cell,
pubmed-meshheading:6189601-Carcinoma, Squamous Cell,
pubmed-meshheading:6189601-Clinical Trials as Topic,
pubmed-meshheading:6189601-Drug Therapy, Combination,
pubmed-meshheading:6189601-Female,
pubmed-meshheading:6189601-Humans,
pubmed-meshheading:6189601-Lung Neoplasms,
pubmed-meshheading:6189601-Male,
pubmed-meshheading:6189601-Middle Aged,
pubmed-meshheading:6189601-Mitomycins,
pubmed-meshheading:6189601-Peplomycin,
pubmed-meshheading:6189601-Random Allocation
|
pubmed:year |
1983
|
pubmed:articleTitle |
Effect of peplomycin plus carbazilquinone and mitomycin on non-small cell carcinoma of the lung.
|
pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
|