Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1983-7-8
pubmed:abstractText
The effects of two chemotherapeutic regimens, peplomycin (PLM) plus carbazilquinone and PLM plus mitomycin, on non-small cell carcinoma of the lung were evaluated by a randomized controlled trial. Seven partial responses were observed in 53 evaluable patients, for an overall response rate of 13.2%. There was no difference in response rate or in median survival time between PLM plus carbazilquinone (11.5% and 32 weeks) and PLM plus mitomycin (14.8% and 25 weeks). Seven patients developed interstitial pneumonitis, and four died of pulmonary fibrosis. It was concluded that the chemotherapeutic regimens that include PLM are only marginally effective against non-small cell carcinoma of the lung, with relatively frequent pulmonary fibrosis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0361-5960
pubmed:author
pubmed:issnType
Print
pubmed:volume
67
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
385-7
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:6189601-Adenocarcinoma, pubmed-meshheading:6189601-Adult, pubmed-meshheading:6189601-Aged, pubmed-meshheading:6189601-Antibiotics, Antineoplastic, pubmed-meshheading:6189601-Azirines, pubmed-meshheading:6189601-Bleomycin, pubmed-meshheading:6189601-Carbazilquinone, pubmed-meshheading:6189601-Carcinoma, Small Cell, pubmed-meshheading:6189601-Carcinoma, Squamous Cell, pubmed-meshheading:6189601-Clinical Trials as Topic, pubmed-meshheading:6189601-Drug Therapy, Combination, pubmed-meshheading:6189601-Female, pubmed-meshheading:6189601-Humans, pubmed-meshheading:6189601-Lung Neoplasms, pubmed-meshheading:6189601-Male, pubmed-meshheading:6189601-Middle Aged, pubmed-meshheading:6189601-Mitomycins, pubmed-meshheading:6189601-Peplomycin, pubmed-meshheading:6189601-Random Allocation
pubmed:year
1983
pubmed:articleTitle
Effect of peplomycin plus carbazilquinone and mitomycin on non-small cell carcinoma of the lung.
pubmed:publicationType
Journal Article, Clinical Trial, Comparative Study, Randomized Controlled Trial, Research Support, Non-U.S. Gov't