Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1983-6-10
pubmed:abstractText
The time course of the spasmogenic effect of substance P (SP) on the longitudinal muscle (LM) of the guinea-pig ileum was investigated. Maximum effective concentrations of SP (greater than or equal to 10 ng/ml) produced a fast initial response which subsequently declined to about 50% of the initial contraction. This remaining half-maximum contraction was increased by physostigmine and decreased by tropicamide, morphine, and tetrodotoxin; hexamethonium had no effect. The results indicate that SP, apart from its direct action on the LM, also activates cholinergic neurones innervating the LM.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0304-3940
pubmed:author
pubmed:issnType
Print
pubmed:volume
17
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
101-5
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1980
pubmed:articleTitle
Neurally mediated contraction of ileal longitudinal muscle by substance P.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't