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Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1-2
|
pubmed:dateCreated |
1983-6-10
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pubmed:abstractText |
The time course of the spasmogenic effect of substance P (SP) on the longitudinal muscle (LM) of the guinea-pig ileum was investigated. Maximum effective concentrations of SP (greater than or equal to 10 ng/ml) produced a fast initial response which subsequently declined to about 50% of the initial contraction. This remaining half-maximum contraction was increased by physostigmine and decreased by tropicamide, morphine, and tetrodotoxin; hexamethonium had no effect. The results indicate that SP, apart from its direct action on the LM, also activates cholinergic neurones innervating the LM.
|
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Apr
|
pubmed:issn |
0304-3940
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
17
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
101-5
|
pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:6189007-Animals,
pubmed-meshheading:6189007-Cholinergic Fibers,
pubmed-meshheading:6189007-Drug Interactions,
pubmed-meshheading:6189007-Female,
pubmed-meshheading:6189007-Guinea Pigs,
pubmed-meshheading:6189007-Ileum,
pubmed-meshheading:6189007-Male,
pubmed-meshheading:6189007-Muscle, Smooth,
pubmed-meshheading:6189007-Muscle Contraction,
pubmed-meshheading:6189007-Neuromuscular Junction,
pubmed-meshheading:6189007-Substance P
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pubmed:year |
1980
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pubmed:articleTitle |
Neurally mediated contraction of ileal longitudinal muscle by substance P.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
|