Linked Life Data

6188629

Source:http://linkedlifedata.com/resource/pubmed/id/6188629

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1983-6-10
pubmed:abstractText
The rate of release of a secretory enzyme, alpha-amylase, from the parotid lobules of 2 and 24 month old rats has been compared to determine whether the secretory activity of the cells change during aging. Upon incubation in the presence of a secretogogue, isoproterenol (10(-5) M), about the same proportions of the glandular alpha-amylase are released at about the same rate from these lobules. The isoproterenol-stimulated release of the enzyme is inhibited nearly completely by preincubating the lobules with propranolol (10(-5) M) in both age groups, indicating that the enzyme secretion occurs through the stimulation of beta-receptors. When viewed in the electron microscope, the cell membranes bordering the secretory lumen in isoproterenol-incubated lobules reveal festooned appearances which suggest that the enzyme release occurs by means of exocytosis. These observations indicate that the ability of the parotid cells to release secretory products through the beta-receptor mediation does not significantly change with increasing age.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0531-5565
pubmed:author
pubmed:issnType
Print
pubmed:volume
17
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
387-97
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Secretion of alpha-amylase from parotid lobules of young and old rats.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, U.S. Gov't, Non-P.H.S.