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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
1983-5-5
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pubmed:abstractText |
Structural studies and quantitative analyses were conducted on the hemoglobin of 55 newborn babies. Seven alpha chain variants (G-Philadelphia, Montgomery, Inkster, I-Philadelphia, Matsue-Oki, Winnipeg, and O-Indonesia) were present in 26 heterozygous newborns (17 black, eight Caucasian, and one Indonesian). The relative amount of the alpha X containing abnormal Hb F of the Hb G-Philadelphia and Hb Winnipeg babies was less than observed in heterozygous adults, which may indicate a decreased rate of assembly of the alpha X-gamma dimer over that of the alpha X-beta dimer. Of the 29 newborns with gamma chain variants, 16 were Caucasian babies; of these 15 had a Hb A gamma F-Hull heterozygosity and one a Hb G gamma F-Marietta heterozygosity. Six black babies were heterozygous for Hb A gamma F-Texas-I and six for Hb G gamma F-Port Royal. One Japanese baby had a heterozygosity for A gamma F-Iwata and a second was heterozygous for A gamma TF-Yamaguchi. Quantitative analyses of the isolated normal Hb Fo as well as an evaluation of the relative amounts of the Hb Fx in the red cell lysates gave data useful for a speculation of the genetic condition in each of these babies. It was concluded that the babies with the Hbs F-Texas-I, F-Iwata, F-Hull, and F-Marietta were simple heterozygotes with either the G gamma x A gamma/G gamma x A gamma X or the G gamma x A gamma/G gamma X x A gamma genic arrangement. The babies with Hb F-Port Royal had a G gamma x G gamma X/G gamma x A gamma arrangement, which may result from a (to be determined) gene conversion. The newborn baby with Hb F-Yamaguchi has the G gamma x A gamma x/A gamma T-X.-. genic arrangement, suggesting the presence of three distinctly different gamma chain genes of which one, the A gamma T-X gene, produces an A gamma chain (with threonyl at position gamma 75 and an Asn at position gamma 80) at a level usually seen for G gamma rather than A gamma chains. These studies were greatly facilitated by the use of high pressure liquid chromatographic methods.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Fetal Hemoglobin,
http://linkedlifedata.com/resource/pubmed/chemical/Hemoglobin M,
http://linkedlifedata.com/resource/pubmed/chemical/Hemoglobins, Abnormal,
http://linkedlifedata.com/resource/pubmed/chemical/hemoglobin F Iwata,
http://linkedlifedata.com/resource/pubmed/chemical/hemoglobin F Yamaguchi,
http://linkedlifedata.com/resource/pubmed/chemical/hemoglobin G Philadelphia,
http://linkedlifedata.com/resource/pubmed/chemical/hemoglobin M Iwate
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0361-8609
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
121-32
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:6188374-Amino Acid Sequence,
pubmed-meshheading:6188374-Fetal Blood,
pubmed-meshheading:6188374-Fetal Hemoglobin,
pubmed-meshheading:6188374-Hemoglobin M,
pubmed-meshheading:6188374-Hemoglobinopathies,
pubmed-meshheading:6188374-Hemoglobins, Abnormal,
pubmed-meshheading:6188374-Humans,
pubmed-meshheading:6188374-Infant, Newborn,
pubmed-meshheading:6188374-Infant, Newborn, Diseases
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pubmed:year |
1983
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pubmed:articleTitle |
alpha Chain and gamma chain abnormal hemoglobins in newborn babies: structural and genetic aspects.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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