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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1983-5-5
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pubmed:abstractText |
NIARD (non-immunoglobulin-associated rearranging DNA) is located on mouse chromosome 15 at the break point of a commonly observed translocation event involving chromosomes 15 and 12 in murine plasmacytomas. The human cellular analogue of the v-myc oncogene of avian myelocytomatosis virus, strain MC-29, is known to reside on the distal end of human chromosome 8 and has been observed to translocate to chromosome 14 in Burkitt lymphomas. Using a cDNA clone specific for the transcript of the human c-myc gene (H c-myc), we show that the mouse c-myc (M c-myc) gene is contained within NIARD. NIARD-associated chromosome translocations occurred 1.3-2 kilobases (kb) 5' of the mouse c-myc gene where NIARD recombines with the switch region of the C(alpha) immunoglobulin gene in various murine plasmacytomas. The mouse c-myc encoding region within NIARD spanned <2.4 kb of DNA and expressed a low level of a 2.3-kb polyadenylylated RNA in BALB/c spleen. Increased (10- to 20-fold) levels of rearranged mouse c-myc transcripts (i.e., approximately 1.8-2.1 kb) were observed in plasmacytomas that have NIARD-associated chromosome translocations. Human c-myc and NIARD probes detected DNA rearrangements of human c-myc in four of seven Burkitt lymphomas. DNA sequences adjacent to the human c-myc gene recombined with the C(mu) immunoglobulin gene locus on chromosome 14 in several Burkitt lymphomas. The activation of the c-myc oncogene by chromosome translocation implicates its involvement in B-cell oncogenesis.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6188153-103631,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6188153-114999,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6188153-1195397,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6188153-4113130,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6188153-418805,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6188153-518835,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6188153-519762,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6188153-6159641,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6188153-6258797,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6188153-6258798,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6188153-6261142,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6188153-6262810,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6188153-6285471,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6188153-6286763,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6188153-6287471,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6188153-6292905,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6188153-6294668,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6188153-6801764,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6188153-6813863,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6188153-6959142,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6188153-6960358,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6188153-6961453,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6188153-7049837,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6188153-7063039,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6188153-7312030,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6188153-7444720,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6188153-946170
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
80
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
519-23
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:6188153-Animals,
pubmed-meshheading:6188153-Base Sequence,
pubmed-meshheading:6188153-Burkitt Lymphoma,
pubmed-meshheading:6188153-DNA Restriction Enzymes,
pubmed-meshheading:6188153-Humans,
pubmed-meshheading:6188153-Liver,
pubmed-meshheading:6188153-Mice,
pubmed-meshheading:6188153-Mice, Inbred BALB C,
pubmed-meshheading:6188153-Neoplasms, Experimental,
pubmed-meshheading:6188153-Oncogenes,
pubmed-meshheading:6188153-Plasmacytoma,
pubmed-meshheading:6188153-Poly A,
pubmed-meshheading:6188153-RNA,
pubmed-meshheading:6188153-RNA, Messenger,
pubmed-meshheading:6188153-Spleen,
pubmed-meshheading:6188153-Transcription, Genetic,
pubmed-meshheading:6188153-Translocation, Genetic
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pubmed:year |
1983
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pubmed:articleTitle |
Transcriptionally active c-myc oncogene is contained within NIARD, a DNA sequence associated with chromosome translocations in B-cell neoplasia.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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