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rdf:type |
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lifeskim:mentions |
umls-concept:C0007634,
umls-concept:C0019588,
umls-concept:C0026249,
umls-concept:C0033268,
umls-concept:C0037993,
umls-concept:C0039194,
umls-concept:C0079460,
umls-concept:C0871261,
umls-concept:C1322978,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2349975,
umls-concept:C2911692
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pubmed:issue |
5
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pubmed:dateCreated |
1983-5-27
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pubmed:abstractText |
In response to T cell mitogens, spleen cells produce a large amount of histamine, whereas no or a slight increase is observed after B cell mitogen stimulation. This increased histamine production results from the effect of a factor having all the characteristics of HCSF (histamine-producing cell-stimulating factor) already described in secondary MLC supernatant. This factor is produced by Thy-1, 2, Lyt-1, 2-positive cells. Spleen cell cultures derived from skin-allografted mice during rejection produce more histamine in response to T cell mitogens than do spleen cells from normal or syngeneic grafted mice. Such a phenomenon is not observed in response to B cell mitogens. A striking association is found between enhanced histamine synthesis and skin allograft rejection. This phenomenon results from a) a five to 10-fold increase in HCSF production by allograft recipient spleen cells in response to T cell mitogens, and b) an increase in HCSF sensitivity of these spleen cells.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0022-1767
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
130
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2343-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:6187852-Animals,
pubmed-meshheading:6187852-Antigens, Surface,
pubmed-meshheading:6187852-Antigens, Thy-1,
pubmed-meshheading:6187852-Antilymphocyte Serum,
pubmed-meshheading:6187852-Bone Marrow,
pubmed-meshheading:6187852-Bone Marrow Cells,
pubmed-meshheading:6187852-Concanavalin A,
pubmed-meshheading:6187852-Histamine Release,
pubmed-meshheading:6187852-Isoantigens,
pubmed-meshheading:6187852-Lymphocyte Activation,
pubmed-meshheading:6187852-Lymphokines,
pubmed-meshheading:6187852-Mice,
pubmed-meshheading:6187852-Mice, Inbred C57BL,
pubmed-meshheading:6187852-Mice, Inbred DBA,
pubmed-meshheading:6187852-Phytohemagglutinins,
pubmed-meshheading:6187852-Skin Transplantation,
pubmed-meshheading:6187852-Spleen,
pubmed-meshheading:6187852-T-Lymphocytes
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pubmed:year |
1983
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pubmed:articleTitle |
Skin allografts generate an enhanced production of histamine and histamine-producing cell-stimulating factor (HCSF) by spleen cells in response to T cell mitogens.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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