| pubmed-article:6187695 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:6187695 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:6187695 | lifeskim:mentions | umls-concept:C0029923 | lld:lifeskim |
| pubmed-article:6187695 | lifeskim:mentions | umls-concept:C0020846 | lld:lifeskim |
| pubmed-article:6187695 | lifeskim:mentions | umls-concept:C0038856 | lld:lifeskim |
| pubmed-article:6187695 | lifeskim:mentions | umls-concept:C0332293 | lld:lifeskim |
| pubmed-article:6187695 | lifeskim:mentions | umls-concept:C0127400 | lld:lifeskim |
| pubmed-article:6187695 | lifeskim:mentions | umls-concept:C0301625 | lld:lifeskim |
| pubmed-article:6187695 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:6187695 | pubmed:dateCreated | 1983-5-27 | lld:pubmed |
| pubmed-article:6187695 | pubmed:abstractText | Various size polymers are obtained following glutaraldehyde treatment of native ovalbumin (OA). OA-POL, approximately 35 X 10(6) daltons, was prepared at the isoelectric point of OA. Treatment of CBA mice with microgram amounts of OA-POL led to efficient antigen-specific suppression of IgE responses. IgG anti-OA antibodies were not suppressed. Transfer of cells from OA-POL-treated donors into normal, unprimed recipients interfered with the ability of these animals to mount a primary or secondary IgE response. In addition, cotransfer of spleen cells from OA-POL-treated mice along with OA (in alum)-primed cells, into irradiated syngeneic recipients resulted in IgE class-specific suppression that was abrogated by treatment of OA-POL donor cells with monoclonal anti-Thy 1.2 + complement. The presence or absence of T cells in the OA-POL population had no effect on IgG levels in the recipients. Analysis of the antigenic properties of OA-POL revealed 5-15% cross-reactivity with native OA as perceived by IgG or IgE antibodies. In contrast, OA-POL was highly cross-reactive at the T cell level as shown functionally by its potent induction of OA-specific, IgE-selective suppressor T cells. The results suggest that the beneficial effects of glutaraldehyde-modified allergens, recently introduced in the immunotherapy of atopic individuals may be due to the preferential exposure on the polymerized protein, of antigenic determinants generating T suppressor cells and to the selective loss of B cell-reactive determinants. | lld:pubmed |
| pubmed-article:6187695 | pubmed:language | eng | lld:pubmed |
| pubmed-article:6187695 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6187695 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:6187695 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6187695 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6187695 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6187695 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6187695 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6187695 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:6187695 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:6187695 | pubmed:issn | 0020-5915 | lld:pubmed |
| pubmed-article:6187695 | pubmed:author | pubmed-author:StrejanG HGH | lld:pubmed |
| pubmed-article:6187695 | pubmed:author | pubmed-author:HayGlassK TKT | lld:pubmed |
| pubmed-article:6187695 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:6187695 | pubmed:volume | 71 | lld:pubmed |
| pubmed-article:6187695 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:6187695 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:6187695 | pubmed:pagination | 23-31 | lld:pubmed |
| pubmed-article:6187695 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:6187695 | pubmed:meshHeading | pubmed-meshheading:6187695-... | lld:pubmed |
| pubmed-article:6187695 | pubmed:year | 1983 | lld:pubmed |
| pubmed-article:6187695 | pubmed:articleTitle | Antigen- and IgE class-specific suppression mediated by T suppressor cells of mice treated with glutaraldehyde-polymerized ovalbumin. | lld:pubmed |
| pubmed-article:6187695 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:6187695 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:6187695 | lld:pubmed |
