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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1983-5-27
|
| pubmed:abstractText |
Various size polymers are obtained following glutaraldehyde treatment of native ovalbumin (OA). OA-POL, approximately 35 X 10(6) daltons, was prepared at the isoelectric point of OA. Treatment of CBA mice with microgram amounts of OA-POL led to efficient antigen-specific suppression of IgE responses. IgG anti-OA antibodies were not suppressed. Transfer of cells from OA-POL-treated donors into normal, unprimed recipients interfered with the ability of these animals to mount a primary or secondary IgE response. In addition, cotransfer of spleen cells from OA-POL-treated mice along with OA (in alum)-primed cells, into irradiated syngeneic recipients resulted in IgE class-specific suppression that was abrogated by treatment of OA-POL donor cells with monoclonal anti-Thy 1.2 + complement. The presence or absence of T cells in the OA-POL population had no effect on IgG levels in the recipients. Analysis of the antigenic properties of OA-POL revealed 5-15% cross-reactivity with native OA as perceived by IgG or IgE antibodies. In contrast, OA-POL was highly cross-reactive at the T cell level as shown functionally by its potent induction of OA-specific, IgE-selective suppressor T cells. The results suggest that the beneficial effects of glutaraldehyde-modified allergens, recently introduced in the immunotherapy of atopic individuals may be due to the preferential exposure on the polymerized protein, of antigenic determinants generating T suppressor cells and to the selective loss of B cell-reactive determinants.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Epitopes,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin E,
http://linkedlifedata.com/resource/pubmed/chemical/Macromolecular Substances,
http://linkedlifedata.com/resource/pubmed/chemical/Ovalbumin,
http://linkedlifedata.com/resource/pubmed/chemical/Serum Albumin,
http://linkedlifedata.com/resource/pubmed/chemical/polyalbumin
|
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0020-5915
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
71
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
23-31
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:6187695-Animals,
pubmed-meshheading:6187695-Binding, Competitive,
pubmed-meshheading:6187695-Cross Reactions,
pubmed-meshheading:6187695-Epitopes,
pubmed-meshheading:6187695-Female,
pubmed-meshheading:6187695-Immune Tolerance,
pubmed-meshheading:6187695-Immunization, Passive,
pubmed-meshheading:6187695-Immunization, Secondary,
pubmed-meshheading:6187695-Immunoglobulin E,
pubmed-meshheading:6187695-Macromolecular Substances,
pubmed-meshheading:6187695-Male,
pubmed-meshheading:6187695-Mice,
pubmed-meshheading:6187695-Mice, Inbred CBA,
pubmed-meshheading:6187695-Ovalbumin,
pubmed-meshheading:6187695-Passive Cutaneous Anaphylaxis,
pubmed-meshheading:6187695-Rats,
pubmed-meshheading:6187695-Rats, Inbred Strains,
pubmed-meshheading:6187695-Serum Albumin,
pubmed-meshheading:6187695-T-Lymphocytes, Regulatory
|
| pubmed:year |
1983
|
| pubmed:articleTitle |
Antigen- and IgE class-specific suppression mediated by T suppressor cells of mice treated with glutaraldehyde-polymerized ovalbumin.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|