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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1983-5-5
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pubmed:abstractText |
alpha-1-Antitrypsin is found in hepatocytes as a high-mannose glycoprotein (Mr 49 000), extracellularly as a complex-type glycoprotein (Mr 54 000). Deglycosylation of both forms with peptide: N-glycosidase led to proteins of identical app. Mr (41 000). The sequence of 26 N-terminal amino acids of rat alpha 1-antitrypsin was determined. A high content of polar amino acids was found. The partially characterized presequence of in vitro synthesized alpha 1-antitrypsin showed a cluster of hydrophobic amino acids. A pre-peptide of 24 amino acids is proposed. There is no evidence for the existence of a propeptide.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0014-5793
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
24
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pubmed:volume |
151
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
201-5
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:6187600-Amino Acid Sequence,
pubmed-meshheading:6187600-Animals,
pubmed-meshheading:6187600-Humans,
pubmed-meshheading:6187600-Liver,
pubmed-meshheading:6187600-Plants,
pubmed-meshheading:6187600-Poly A,
pubmed-meshheading:6187600-Protein Biosynthesis,
pubmed-meshheading:6187600-Protein Precursors,
pubmed-meshheading:6187600-RNA,
pubmed-meshheading:6187600-RNA, Messenger,
pubmed-meshheading:6187600-Rats,
pubmed-meshheading:6187600-Species Specificity,
pubmed-meshheading:6187600-Triticum,
pubmed-meshheading:6187600-alpha 1-Antitrypsin
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pubmed:year |
1983
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pubmed:articleTitle |
N-terminal amino acid sequences of precursor and mature forms of alpha-1-antitrypsin.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
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