Linked Life Data

61875

Source:http://linkedlifedata.com/resource/pubmed/id/61875

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
1977-1-3
pubmed:abstractText
The preferential take of tumors after small-size inocula of transplantable tumor cells has been described for many systems. The phenomenon has been named "sneaking through" or "dilution escape". Using a BALB/c mastocytoma, we have analyzed the immunological parameters accompanying sneaking through that can be observed upon injection of 10(1) to 10(3) living cells. Mice can also be conditioned by injection of low, subimmunogenic numbers of irradiated cells to show increased tumor incidences upon injection of living cells in doses two orders of magnitude above the sneaking through dose. The general immune reactivity of the animals is not impaired under these conditions. However, determinant-specific unresponsiveness is found which can be transferred by spleen cells and therefore seems to be actively maintained. It is concluded that sneaking through of tumor cells is the result of specific immunological impairment of the host's immune system by subimmunogenic small-size inocula of tumor cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0014-2980
pubmed:author
pubmed:issnType
Print
pubmed:volume
5
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
532-7
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1975
pubmed:articleTitle
Correlation of "sneaking through" of tumor cells with specific immunological impairment of the host.
pubmed:publicationType
Journal Article