Linked Life Data

6187255

Source:http://linkedlifedata.com/resource/pubmed/id/6187255

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1983-4-15
pubmed:abstractText
Adriamycin levels are usually determined in biologic samples (tissue homogenates) by means of spectrophotofluorimetric procedures. After intravenous administration of a pharmacologic dose of Adriamycin to 21 female Swiss mice, the fluorescence released from the nuclei of single liver and kidney cells was determined by cytofluorimetric measurements on 3,916 in-vivo-treated liver cells and 1,472 in-vivo-treated kidney cells. Similar measurements were made on 287 untreated (control) liver cells and 288 untreated kidney cells as well as on 541 liver cells and 773 kidney cells stained in vitro with acriflavine. The results indicate that (1) it is possible to quantitatively evaluate the nuclear uptake of Adriamycin in in vivo single cells by cytofluorimetry, (2) the pharmacokinetics of Adriamycin can be evaluated on the cellular level and (3) Adriamycin can be considered a fluorochrome suitable for in vivo staining of cell nuclei as can acriflavine for the in vitro staining of cell nuclei.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0190-0471
pubmed:author
pubmed:issnType
Print
pubmed:volume
4
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
295-301
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Cytophotometric analysis of the nuclear uptake of adriamycin in in vivo normal mouse liver and kidney cells.
pubmed:publicationType
Journal Article