Linked Life Data

6186451

Source:http://linkedlifedata.com/resource/pubmed/id/6186451

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5-6
pubmed:dateCreated
1983-4-15
pubmed:abstractText
Normal levels of serotonin and 5-hydroxyindoleacetic (5-HIAA) were measured in the developing rat spinal cord and brain stem using HPLC. Serotonin, 5-HIAA and 3H-naloxone binding were monitored following neonatal 5,7-dihydroxytryptamine (5,7-DHT) treatment. Serotonin in the spinal cord develops biphasically with peaks at gestation day 21 (E21) and postnatal day 8 (P8) while 5-HIAA peaks at P3 and between P8 and P11. In the brain stem, serotonin gradually rises from E15 to adult levels which are reached by P32 while 5-HIAA rises sharply to P15 and thereafter decreases to adult levels by P32. 5,7-DHT treatment neonatally causes greater than 50% reduction of serotonin and 5-HIAA in the spinal cord through P32. Opiate receptor binding in the spinal cord is reduced acutely by about 22% and remains slightly depressed into adulthood.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0378-5866
pubmed:author
pubmed:issnType
Print
pubmed:volume
5
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
394-402
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Developmental changes in serotonin and 5-hydroxyindoleacetic acid concentrations and opiate receptor binding in rat spinal cord following neonatal 5,7-dihydroxytryptamine treatment.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.