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rdf:type |
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lifeskim:mentions |
umls-concept:C0003340,
umls-concept:C0004561,
umls-concept:C0007589,
umls-concept:C0025260,
umls-concept:C0079411,
umls-concept:C0085820,
umls-concept:C0205263,
umls-concept:C0243072,
umls-concept:C0349590,
umls-concept:C0439662,
umls-concept:C0560175,
umls-concept:C1511938,
umls-concept:C1521751,
umls-concept:C1706209
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pubmed:issue |
1
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pubmed:dateCreated |
1983-4-15
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pubmed:abstractText |
It has been previously reported that trinitrophenylated lipopolysaccharide (TNP-LPS), a thymus-independent (TI)-1 antigen, elicits an anamnestic response to TNP in C57BL/6 mice. The ability of these mice to mount a secondary response to TI-2 antigens was analyzed. Priming with DNP-Ficoll or DNP-Dextran, both TI-2 antigens, resulted in an increased frequency of TNP-binding B lymphocytes. Evidence is presented that memory cell-induction by DNP-Ficoll does not require functional T cells. The differentiation into antibody-forming cells (AFC) of memory cells generated by DNP-Dextran or DNP-Ficoll cannot be obtained by a challenge with either antigen. There was no indication that the lack of a secondary response to TI-2 antigens was related to suppressive T cells interfering with memory expression. Memory cells induced by DNP-Dextran or DNP-Ficoll can nevertheless be activated by TNP-LPS. In contrast to the restricted sensitivity of TNP-memory cells generated by TI-2 antigens, TNP-LPS-induced memory cells are indifferently susceptible to TI-1 or TI-2 antigenic stimulation. These results are discussed in terms of memory B-cell subpopulations.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0008-8749
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
75
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
52-62
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:6186402-Animals,
pubmed-meshheading:6186402-Antibody-Producing Cells,
pubmed-meshheading:6186402-Antigens, T-Independent,
pubmed-meshheading:6186402-B-Lymphocytes,
pubmed-meshheading:6186402-Cell Differentiation,
pubmed-meshheading:6186402-Dextrans,
pubmed-meshheading:6186402-Dinitrobenzenes,
pubmed-meshheading:6186402-Female,
pubmed-meshheading:6186402-Ficoll,
pubmed-meshheading:6186402-Immunization, Passive,
pubmed-meshheading:6186402-Immunologic Memory,
pubmed-meshheading:6186402-Lipopolysaccharides,
pubmed-meshheading:6186402-Male,
pubmed-meshheading:6186402-Mice,
pubmed-meshheading:6186402-Mice, Inbred C57BL,
pubmed-meshheading:6186402-Nitrobenzenes,
pubmed-meshheading:6186402-T-Lymphocytes, Regulatory,
pubmed-meshheading:6186402-Trinitrobenzenes
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pubmed:year |
1983
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pubmed:articleTitle |
Generation of immune memory by haptenated derivatives of thymus-independent antigens in C57BL/6 mice. I. The differentiation of memory B lymphocytes into antibody-secreting cells depends on the nature of the thymus-independent carrier used for memory induction and/or revelation.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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