Linked Life Data

6185677

Source:http://linkedlifedata.com/resource/pubmed/id/6185677

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1983-3-17
pubmed:abstractText
Identification and characterization of the many cellular and subcellular changes that underlie various macrophage functions have been hampered by the problem of population heterogeneity. The problem has remained because, in the case of most functions, we have not had the means to examine cells at a level below that of whole populations. We report here the potential means to do so. Rat anti-mouse mononuclear phagocyte monoclonal antibodies were raised against adherent cells cultured from bone marrow. These antibodies were used to delineate and, in the presence of complement, eliminate subpopulations of macrophages. The extent to which antigenic heterogeneity occurs was shown in several mononuclear phagocyte populations that are commonly employed experimentally. Some antibodies reacted with most mononuclear phagocytes tested, whereas others showed marked selectivity of binding. As expected, resident populations were less heterogeneous antigenically than inflammatory populations were. The data both extend what is known about mononuclear phagocyte population heterogeneity and suggest means by way of which this heterogeneity can be overcome.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0033-6890
pubmed:author
pubmed:issnType
Print
pubmed:volume
32
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
219-31
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Mouse mononuclear phagocyte antigenic heterogeneity detected by monoclonal antibodies.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.