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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
1983-3-24
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pubmed:abstractText |
It was previously demonstrated that the murine humoral immune responses to the common a and subtype-specific d determinants of HBsAg are H-2 restricted. The H-2q haplotype confers high responsiveness and the H-2s haplotype low responsiveness to nonresponsiveness to both determinants. We have now demonstrated that the H-2s haplotype also confers nonresponsiveness to the subtype-specific y determinant as well. Studies of H-2 congenic (nonresponder X responder)F1 and backcross mice indicated that responsiveness was inherited as a dominant trait, with no gene dosage effects observed. Qualitative characteristics of the humoral anti-a and anti-d responses were evaluated with respect to strain variation, kinetics, antigen specificity and antibody titer, affinity, and subclass distribution. Unique immune response patterns were observed for each H-2 haplotype studied. On the basis of these patterns, it was possible to construct a hierarchy of responsiveness to HBsAg of the ad subtype as follows: high responders, H-2q and H-2d; intermediate responders, H-2a greater than H-2b greater than H-2k; and nonresponders, H-2s.
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/Epitopes,
http://linkedlifedata.com/resource/pubmed/chemical/H-2 Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Hepatitis B Antibodies,
http://linkedlifedata.com/resource/pubmed/chemical/Hepatitis B Surface Antigens
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0022-1767
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
130
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1395-400
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:6185581-Animals,
pubmed-meshheading:6185581-Antibodies, Viral,
pubmed-meshheading:6185581-Antibody Affinity,
pubmed-meshheading:6185581-Crosses, Genetic,
pubmed-meshheading:6185581-Epitopes,
pubmed-meshheading:6185581-Female,
pubmed-meshheading:6185581-Genes, MHC Class II,
pubmed-meshheading:6185581-H-2 Antigens,
pubmed-meshheading:6185581-Haploidy,
pubmed-meshheading:6185581-Hepatitis B Antibodies,
pubmed-meshheading:6185581-Hepatitis B Surface Antigens,
pubmed-meshheading:6185581-Kinetics,
pubmed-meshheading:6185581-Mice,
pubmed-meshheading:6185581-Mice, Inbred A,
pubmed-meshheading:6185581-Mice, Inbred BALB C,
pubmed-meshheading:6185581-Mice, Inbred C3H,
pubmed-meshheading:6185581-Mice, Inbred C57BL,
pubmed-meshheading:6185581-Mice, Inbred CBA
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pubmed:year |
1983
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pubmed:articleTitle |
Genetic regulation of the immune response to hepatitis B surface antigen (HBsAg). II. Qualitative characteristics of the humoral immune response to the a, d, and y determinants of HBsAg.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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