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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1983-1-19
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pubmed:abstractText |
Administration of lindane at a dose of 20 mg/kg body weight/day for 15 days to male rats brought about marked growth retardation. Succinic dehydrogenase, Mg2+-ATPase and glucose-6-phosphatase activities were inhibited in different fractions of liver tissues. Mg2+-ATPase, alkaline phosphatase and NADH-dehydrogenase activities were also inhibited in the liver plasma membranes of the lindane treated animals. Stimulation of 5'-nucleotidase activity in liver plasma membrane was observed under lindane intoxication. Supplementation of L-ascorbic acid by separate oral administration to the lindane intoxicated rats neutralized the growth retardation and maintained almost normal values of all the enzymes studied.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adenosine Triphosphatases,
http://linkedlifedata.com/resource/pubmed/chemical/Alkaline Phosphatase,
http://linkedlifedata.com/resource/pubmed/chemical/Ascorbic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/Ca(2 ) Mg(2 )-ATPase,
http://linkedlifedata.com/resource/pubmed/chemical/Glucose-6-Phosphatase,
http://linkedlifedata.com/resource/pubmed/chemical/L-Gulonolactone Oxidase,
http://linkedlifedata.com/resource/pubmed/chemical/Lindane,
http://linkedlifedata.com/resource/pubmed/chemical/NADH Dehydrogenase,
http://linkedlifedata.com/resource/pubmed/chemical/Nucleotidases,
http://linkedlifedata.com/resource/pubmed/chemical/Succinate Dehydrogenase,
http://linkedlifedata.com/resource/pubmed/chemical/Sugar Alcohol Dehydrogenases
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pubmed:status |
MEDLINE
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pubmed:issn |
0300-8924
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
4
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
215-20
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:6183953-Adenosine Triphosphatases,
pubmed-meshheading:6183953-Alkaline Phosphatase,
pubmed-meshheading:6183953-Animals,
pubmed-meshheading:6183953-Ascorbic Acid,
pubmed-meshheading:6183953-Ca(2+) Mg(2+)-ATPase,
pubmed-meshheading:6183953-Glucose-6-Phosphatase,
pubmed-meshheading:6183953-Growth,
pubmed-meshheading:6183953-L-Gulonolactone Oxidase,
pubmed-meshheading:6183953-Lindane,
pubmed-meshheading:6183953-Liver,
pubmed-meshheading:6183953-Male,
pubmed-meshheading:6183953-NADH Dehydrogenase,
pubmed-meshheading:6183953-Nucleotidases,
pubmed-meshheading:6183953-Organ Size,
pubmed-meshheading:6183953-Rats,
pubmed-meshheading:6183953-Rats, Inbred Strains,
pubmed-meshheading:6183953-Succinate Dehydrogenase,
pubmed-meshheading:6183953-Sugar Alcohol Dehydrogenases
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pubmed:year |
1982
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pubmed:articleTitle |
Protective effect of L-ascorbic acid in lindane intoxicated rats.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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