Linked Life Data

6183110

Source:http://linkedlifedata.com/resource/pubmed/id/6183110

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1983-1-7
pubmed:abstractText
A subline of an x-ray-induced transplantable rat insulinoma has been studied in vivo and in vitro. Tumors grew rapidly after sc transplantation and were rich in insulin, but contained only small amounts of glucagon and somatostatin. Despite marked basal hyperinsulinemia, iv glucose administration caused a further increase in plasma insulin in tumor-bearing rats. When the pancreas was functionally excluded by ligation of supplying arteries, glucose still elicited a clear insulin response. In vitro, insulin release from perifused tumor fragments was stimulated by the combination of glucose and 3-isobutyl-1-methylxanthine, but not by glucose alone. In contrast, there was a clear stimulation of insulin release by glucose in primary monolayer cultures of tumor cells. This suggests a better functional capacity of the cultured cells compared to that of the tumor fragments. The results indicate that this transplantable rat islet cell tumor is a convenient source of large quantities of functional beta-cells.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0013-7227
pubmed:author
pubmed:issnType
Print
pubmed:volume
111
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2091-6
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Stimulation of insulin release by glucose in a transplantable rat islet cell tumor.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't