Linked Life Data

6182822

Source:http://linkedlifedata.com/resource/pubmed/id/6182822

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1982-12-18
pubmed:abstractText
Authors have studied pharmacokinetic parameters of theophylline in a sample of 21 children with bronchial asthma, through evolution of plasmatic concentrations, evaluated by RIA, in order to appreciate therapeutic response to it depending on the time-variation of such concentrations. They have determined that theophylline's kinetic obeys to a "depending dose" reaction represented by Michaelis-Menten equation. This induce them to refuse those therapeutic methods based on the establishment of maintaining doses depending on drug clearance, as minimal increases in posology can give spectacular decreases of drug clearance. They have also seen that great amplitude of individual variation for pharmacokinetics parameters of theophylline, in intra-patient studies is very short.
pubmed:language
spa
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0302-4342
pubmed:author
pubmed:issnType
Print
pubmed:volume
17
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
6-17
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
[Pharmacokinetics of theophylline in infantile bronchial asthma. Clinical findings].
pubmed:publicationType
Journal Article, English Abstract