Linked Life Data

6182438

Source:http://linkedlifedata.com/resource/pubmed/id/6182438

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
7
pubmed:dateCreated
1982-12-16
pubmed:abstractText
A general decline in gene expression, translation and transcription, has been observed to occur with increasing age in a wide variety of organisms and tissues. Because the level of most enzymes and proteins remains relatively constant with increasing age, one would predict that the decline in gene expression would result in an age-related decline in protein turnover. Recent studies show that protein turnover in mouse liver and nematodes declines with increasing age. The decline in protein turnover could lead to an age-related decrease in the response of inducible enzymes to stimuli. This could explain the molecular basis for the decline in aging organisms to respond to a variety of environmental factors.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0024-3205
pubmed:author
pubmed:issnType
Print
pubmed:day
16
pubmed:volume
31
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
605-13
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Current concepts: I. The relationship between age-related changes in gene expression, protein turnover, and the responsiveness of an organism to stimuli.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Review