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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
5
|
| pubmed:dateCreated |
1982-12-16
|
| pubmed:abstractText |
We measured coronary sinus blood flow by continuous thermodilution technique and aortic pressure after administration of diltiazem to 23 patients with coronary artery disease. In one group of patients (n = 12) the drug was infused at a rate of 0.15 mg/kg during 2 min followed by an infusion of 0.05 mg/kg during 8 min. Heart rate was unchanged except at 5 min when it decreased slightly. Aortic pressure was significantly (p less than 0.01) decreased, while coronary sinus flow increased slightly and transiently. A second group of patients (n = 5) received an intracoronary injection of 0.15 mg/kg of diltiazem into the left coronary artery. In a third group of patients (n = 7) 0.05 mg/kg of diltiazem was injected into the left coronary artery. In both these two groups the drug induced a marked increase of coronary sinus flow and a decrease of aortic pressure, while myocardial oxygen consumption was unchanged. This effect was dose related, since the rise in coronary flow was 47% with an injection of 0.15 mg/kg but only 23% with a dose of 0.05 mg-kg. These changes were short-lasting with values returning to normal within 10 min after the injection. We conclude that diltiazem is a potent dilator of coronary arteries.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0160-2446
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
4
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
695-9
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:6182397-Adult,
pubmed-meshheading:6182397-Aged,
pubmed-meshheading:6182397-Benzazepines,
pubmed-meshheading:6182397-Blood Flow Velocity,
pubmed-meshheading:6182397-Blood Pressure,
pubmed-meshheading:6182397-Coronary Circulation,
pubmed-meshheading:6182397-Coronary Disease,
pubmed-meshheading:6182397-Coronary Vessels,
pubmed-meshheading:6182397-Diltiazem,
pubmed-meshheading:6182397-Female,
pubmed-meshheading:6182397-Heart Catheterization,
pubmed-meshheading:6182397-Heart Rate,
pubmed-meshheading:6182397-Hemodynamics,
pubmed-meshheading:6182397-Humans,
pubmed-meshheading:6182397-Infusions, Parenteral,
pubmed-meshheading:6182397-Injections, Intra-Arterial,
pubmed-meshheading:6182397-Male,
pubmed-meshheading:6182397-Middle Aged
|
| pubmed:articleTitle |
Coronary hemodynamics following intravenous or intracoronary injection of diltiazem in man.
|
| pubmed:publicationType |
Journal Article
|