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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1982-12-16
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pubmed:abstractText |
C57BL/6 and C3H/HeJ mice were infected intravenously with 6 X 10(5) yeast-phase Histoplasma capsulatum organisms. After 1 week, splenocytes from both mouse strains showed diminished antibody responses to sheep erythrocytes in vitro; these cells also were able to suppress the response of normal syngeneic cells. Passage of splenocytes from infected mice through a nylon wool column yielded a population enriched for T cells that exerted suppressor activity, although to a smaller extent than did unfractionated cells. Treatment of the T-cell-enriched population from both strains of mice with either anti-Thy 1.2 or anti-Ly 2 and complement resulted in a loss of this immunosuppressive ability. In addition, anti-I-Jk antiserum was effective in ablating the suppressive effect of C3H/HeJ nylon wool-passed spleen cells. The conclusion drawn from these experiments is that the T cells from H. capsulatum-infected animals which are capable of modulating the in vitro plaque-forming cell response to sheep erythrocytes bear Ly 2 and I-J determinants on their surfaces.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6182106-1085338,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6182106-1092798,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6182106-1092799,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6182106-306405,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6182106-313371,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6182106-313956,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6182106-361890,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6182106-376352,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6182106-398327,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6182106-457263,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6182106-4587740,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6182106-56011,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6182106-5653817,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6182106-6034749,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6182106-6453657,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6182106-6459945,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6182106-6792727,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6182106-6972040,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6182106-6972410,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6182106-87465
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Sep
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pubmed:issn |
0019-9567
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
37
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
940-5
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:6182106-Animals,
pubmed-meshheading:6182106-Antibody Formation,
pubmed-meshheading:6182106-Antigens, Ly,
pubmed-meshheading:6182106-Antigens, Surface,
pubmed-meshheading:6182106-Antigens, Thy-1,
pubmed-meshheading:6182106-Cytotoxicity, Immunologic,
pubmed-meshheading:6182106-Epitopes,
pubmed-meshheading:6182106-Histoplasmosis,
pubmed-meshheading:6182106-Male,
pubmed-meshheading:6182106-Mice,
pubmed-meshheading:6182106-Mice, Inbred C3H,
pubmed-meshheading:6182106-Mice, Inbred C57BL,
pubmed-meshheading:6182106-Phenotype,
pubmed-meshheading:6182106-T-Lymphocytes, Regulatory
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pubmed:year |
1982
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pubmed:articleTitle |
Immunoregulation in disseminated histoplasmosis: characterization of the surface phenotype of splenic suppressor T lymphocytes.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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