Linked Life Data

6181957

Source:http://linkedlifedata.com/resource/pubmed/id/6181957

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1982-12-21
pubmed:abstractText
By histological examination of the exocrine pancreas a triphasic reaction was proven in 46 rats of a wistar strain 1 hour up to 8 weeks after a transduodenal intraductal instillation of an alcoholic amino acid solution (Ethibloc). The first phase, due to both the incorporated substance by itself and an acutely increased intraductal pressure, consists in an interstitial edema with transition into a perilobular pancreatitis, a cytotoxic damage of the acinar and ductal epithelium with focal necrosis of parenchyma and fat-tissue, a sialangiitis and foreign body granulomas. In a second phase, produced by the occlusion of the duct system, a cystofibrosis of the lobuli developed within 7 to 14 days after a preceding hyperplasia and ectasia of intercalated ducts and an atrophy of acini. In a third phase of pancreas injury, starting at the 14th day of experiment, in non-atrophied lobuli a progressive intralobular, supposed autoimmunological, pancreatitis developed. Changes in the activity of serum lipase and -amylase correlated strongly with the morphological findings. The results suggest that at last a nearly complete burnout of the normal rat pancreas is possible by duct occlusion. But for the clinical application the danger of provocation of an acute relapse of chronic pancreatitis might be given by the presence of a secreting parenchyma.
pubmed:language
ger
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0012-1053
pubmed:author
pubmed:issnType
Print
pubmed:volume
42
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
138-47
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
[Pancreatic findings after ductal occlusion in rats. A histological and biochemical study].
pubmed:publicationType
Journal Article, English Abstract