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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
31-32
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pubmed:dateCreated |
1982-10-12
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pubmed:abstractText |
In-vitro growth of tumour-cell colonies of various human solid carcinomas was investigated. Cell-colony formation in-vitro was achieved from single cells in 46 of 81 tumour specimens. The proportion of tumour-cell colonies per number of cultured tumour cells ("cloning efficiency") thus was 1-8 per 1000. Tumour-cell colonies of various carcinomas differed in their morphological appearance, with characteristic cytological in-vitro. Growth of tumour-cell colonies opens up the possibility of performing cytostatic drug sensitivity tests on defined tumour-cell populations of a given individual tumour. Under the influence of various cytostatic drugs tumour-cell colony numbers could be reduced by more than 30% in 27 of 46 tested carcinomas compared with untreated controls.
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pubmed:language |
ger
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Aug
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pubmed:issn |
0012-0472
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
6
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pubmed:volume |
107
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1173-7
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:6179731-Carmustine,
pubmed-meshheading:6179731-Cisplatin,
pubmed-meshheading:6179731-Clone Cells,
pubmed-meshheading:6179731-Doxorubicin,
pubmed-meshheading:6179731-Drug Resistance,
pubmed-meshheading:6179731-Fluorouracil,
pubmed-meshheading:6179731-Humans,
pubmed-meshheading:6179731-Interferons,
pubmed-meshheading:6179731-Methods,
pubmed-meshheading:6179731-Methotrexate,
pubmed-meshheading:6179731-Neoplasms
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pubmed:year |
1982
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pubmed:articleTitle |
[Growth of tumour-cell colonies from human solid tumours (author's transl)].
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pubmed:publicationType |
Journal Article,
In Vitro,
English Abstract
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