Linked Life Data

6179389

Source:http://linkedlifedata.com/resource/pubmed/id/6179389

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1982-9-24
pubmed:abstractText
Effects of the highly lipid soluble barbiturates methohexital and thiopental on potential clamped myelinated nerve fibres were analyzed. Both were found to affect the potassium as well as sodium transport system. The methohexital effect on the potassium system was complex. At low potential values it reduced the permeability, while at high values it increased the permeability as well as slowed down the kinetics. It antagonized the rectification of IK at high potential values caused by increased axoplasmic [Na+]. The effect may be described as a combination of a decreased permeability constant (PK) and a methohexital induced potassium permeability with a potential and time dependence different to the ordinary potassium system. Thiopental reduced PK only. The effect on the sodium system was similar for the studied barbiturates and similar to that described for other barbiturates: a decrease of the permeability constant (PNa) and a shift of the h infinity-U relation in negative direction along the potential axis.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0001-6772
pubmed:author
pubmed:issnType
Print
pubmed:volume
113
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
387-92
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
A barbiturate-induced potassium permeability increase in the myelinated nerve membrane.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't