Linked Life Data

6178909

Source:http://linkedlifedata.com/resource/pubmed/id/6178909

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1982-9-24
pubmed:abstractText
This article deals with the neuropeptides found in the eye and their actions. Substance P (SP) and VIP have been found in the anterior chamber of the eye. Here SP is localized in the sensory nerves of the sclera, cornea, iris, ciliary body and ciliary processes. It is supposed to be a sensory transmitter but can also be liberated by peripheral nerve endings as a response to various trauma. When this happens in the eye, for instance, after irritation of the Vth cranial nerve, SP causes an intense and long lasting miosis and may have some further actions as well. VIP has been demonstrated in nerves (probably cholinergic) of the posterior choroid and ciliary body. It is a potent vasodilator and may regulate choroideal blood flow. The retina is especially rich in different neuropeptides. SP, VIP, neurotensin, enkephalin, somatostatin, glucagon and gonadotropin-releasing hormone have all been demonstrated in the inner plexiform layer of the retina of various animal species. Specific information about the physiological role of retinal neuropeptides is still scarce but research is in progress. Considering the clinical significance of the new information about ocular neuropeptides, SP seems to be the most important substance. Recently a synthetic SP antagonist was reported to block the inflammatory response in the rabbit eye, which suggests a clinical use for this type of compounds.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0302-2137
pubmed:author
pubmed:issnType
Print
pubmed:volume
60
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
53-60
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Ocular neuropeptides.
pubmed:publicationType
Journal Article, Review