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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
1982-9-17
|
| pubmed:abstractText |
BALB/c mice immunized with bacterial levan (BL) produce a vigorous antibody response that fails to include antibodies expressing the idiotype of the beta 2 leads to 6 fructosan-binding myeloma protein ABPC48 (A48). Treatment of newborn BALB/c mice at 1 d of age with 0.1-10 microgram of either the A48 myeloma protein or monoclonal proteins that share idiotopes with the A48 family, followed by immunization with BL 2-4 wk later, produces an anti-BL response that is dominated by the A48Id. Various degrees of activation of the A48Id BL response were observed by injecting mice with A48 monoclonal protein only up until 3 wk of age. Activation of the A48Id clones by treating with A48 monoclonal protein was ineffective in mice who were older than 4 wk. Elicitation of an A48Id BL response required specific antigenic stimulation with either beta 2 leads to 6 or beta 2 leads to 1 fructosan epitopes, because it does not occur after injection with TNP-Ficoll in spite of the A48 treatment. The expansion of A48Id clones in mice treated at birth with A48 monoclonal protein is associated with an increase in A48Id-specific helper T cells. The binding specificity of these cells was demonstrated by infusing them into nu/nu BALB/c mice and observing that they rendered help that enalbed the animal to mount an anti-TNP response after immunization only with A48-TNP, but not with MOPC384-TNP conjugates. The helper activity of these cells is sensitive to the effects of treatment with anti-Lyt-1.2 antibodies plus complement. A predominantly A48Id BL-specific response can be transferred into lethally irradiated mice by infusing them with purified T and B cells from A48-treated mice. The transfer of this response can be ablated by treating the T cells with anti-Lyt-1.2 antibodies plus complement. These results indicate that A48Id-specific helper cells possess the ability to select the A48Id-bearing B cell precursors for expression, thus exerting a fine-tuning effect on the idiotypic expression of the anti-BL repertoire. We propose that this idiotype-induced idiotype response, which can be, in principal, induced by idiotypes provided by the mother, plays an important role in the expansion of precursors of antibody-forming cells during embryonic as well as postnatal life.
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| pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6178788-1079035,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6178788-1151286,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6178788-14097352,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6178788-313743,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6178788-351051,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6178788-396471,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6178788-4142565,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6178788-417140,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6178788-479606,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6178788-5330427,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6178788-5355110,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6178788-60906,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6178788-6156985,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6178788-6158544,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6178788-6175969,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6178788-6782489,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6178788-7019374,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6178788-7252415,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6178788-7297596,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6178788-76433
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Aug
|
| pubmed:issn |
0022-1007
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
1
|
| pubmed:volume |
156
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
506-21
|
| pubmed:dateRevised |
2009-11-18
|
| pubmed:meshHeading |
pubmed-meshheading:6178788-Aging,
pubmed-meshheading:6178788-Animals,
pubmed-meshheading:6178788-Animals, Newborn,
pubmed-meshheading:6178788-Antibodies, Monoclonal,
pubmed-meshheading:6178788-Clone Cells,
pubmed-meshheading:6178788-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:6178788-Epitopes,
pubmed-meshheading:6178788-Hemagglutination Inhibition Tests,
pubmed-meshheading:6178788-Immunoglobulin Idiotypes,
pubmed-meshheading:6178788-Mice,
pubmed-meshheading:6178788-Mice, Inbred BALB C,
pubmed-meshheading:6178788-Mice, Nude,
pubmed-meshheading:6178788-Myeloma Proteins,
pubmed-meshheading:6178788-Radioimmunoassay,
pubmed-meshheading:6178788-Species Specificity,
pubmed-meshheading:6178788-T-Lymphocytes
|
| pubmed:year |
1982
|
| pubmed:articleTitle |
Idiotype-anti-idiotype network. II. Activation of silent clones by treatment at birth with idiotypes is associated with the expansion of idiotype-specific helper T cells.
|
| pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
|