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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1-2
|
pubmed:dateCreated |
1982-7-19
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pubmed:abstractText |
In a preliminary study high doses of the H1-antagonist clemastine (clem) and the H2-antagonist cimetidine (cim) were used in order to detect the side effects of both drugs on allergic reactions. After pretreatment with clem or clem/cim different guinea pigs were challenged with either OA or histamine. Bronchial obstruction was measured by body plethysmography using a new parameter ('compressed air'). Pretreatment with clem/cim in high doses protected guinea pigs against OA-induced bronchial obstruction much more effectively than H1-receptor antagonism alone; lower cim doses produced insignificant effects. In histamine-challenged animals cim showed no protective effects. In vitro clem/cim caused a marked reduction of histamine release measured in perfused lungs from 16.9 +/- 4.2 ng/ml (eight control cases) to 2.8 +/- 1.7 ng/ml (n = 8). Our preliminary data suggest that high doses of clem/cim can protect sensitized guinea pigs against allergen-induced bronchial obstruction by inhibiting histamine release.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Allergens,
http://linkedlifedata.com/resource/pubmed/chemical/Cimetidine,
http://linkedlifedata.com/resource/pubmed/chemical/Clemastine,
http://linkedlifedata.com/resource/pubmed/chemical/Guanidines,
http://linkedlifedata.com/resource/pubmed/chemical/Histamine,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrrolidines
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0065-4299
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
113-8
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:6177209-Allergens,
pubmed-meshheading:6177209-Animals,
pubmed-meshheading:6177209-Cimetidine,
pubmed-meshheading:6177209-Clemastine,
pubmed-meshheading:6177209-Drug Interactions,
pubmed-meshheading:6177209-Exudates and Transudates,
pubmed-meshheading:6177209-Guanidines,
pubmed-meshheading:6177209-Guinea Pigs,
pubmed-meshheading:6177209-Histamine,
pubmed-meshheading:6177209-Histamine Release,
pubmed-meshheading:6177209-Lung,
pubmed-meshheading:6177209-Male,
pubmed-meshheading:6177209-Pyrrolidines,
pubmed-meshheading:6177209-Time Factors
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pubmed:year |
1982
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pubmed:articleTitle |
Histamine1--histamine2 antagonism: effect of combined clemastine and cimetidine pretreatment on allergen and histamine-induced reactions of the guinea pig lung in vivo and in vitro.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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