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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1982-7-19
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pubmed:abstractText |
The spatial relationship for T-B cell cooperation between antigenic epitopes and carrier epitopes on the antigen molecule was studied. Two mono-DNP substituted derivatives of hen egg-white lysozyme (HEL), DNP1-33HEL and DNP1-96HEL were used as antigens; the former is dinitrophenylated only at lysine-33 and the latter only at lysine-96. Fragment peptides of HEL were used to induce specific T cells to the respective sites of the antigen. Adoptive cell-transfer experiments of site-specific T cells and DNP-primed B cells directly showed that multiple distinct carrier epitopes for T cells could help the antibody responses to the single antigenic epitope for B cells and that a single carrier epitope could help antibody responses to multiple antigenic epitopes. T cells primed with a synthetic peptide SP34-54 (corresponding to sequence 34-54 of HEL) co-operated with DNP-primed B cells on challenge with DNP1-96HEL, but not with DNP1-33HEL.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6176535-14301784,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6176535-4101344,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6176535-4112562,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6176535-4116319,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6176535-4118740,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6176535-4141891,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6176535-415110,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6176535-4587740,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6176535-4888629,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6176535-4979775,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6176535-52358,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6176535-5253653,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6176535-6059949,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6176535-7287648,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6176535-7365240,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6176535-88500,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6176535-93548
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0019-2805
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
46
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
145-54
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:6176535-2,4-Dinitrophenol,
pubmed-meshheading:6176535-Animals,
pubmed-meshheading:6176535-Antibody Formation,
pubmed-meshheading:6176535-B-Lymphocytes,
pubmed-meshheading:6176535-Dinitrophenols,
pubmed-meshheading:6176535-Egg White,
pubmed-meshheading:6176535-Epitopes,
pubmed-meshheading:6176535-Mice,
pubmed-meshheading:6176535-Mice, Inbred Strains,
pubmed-meshheading:6176535-Models, Molecular,
pubmed-meshheading:6176535-Muramidase,
pubmed-meshheading:6176535-T-Lymphocytes,
pubmed-meshheading:6176535-Uncoupling Agents
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pubmed:year |
1982
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pubmed:articleTitle |
Structural relationships between carrier epitopes and antigenic epitopes on hen egg-white lysozyme.
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pubmed:publicationType |
Journal Article
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