Linked Life Data

6176493

Source:http://linkedlifedata.com/resource/pubmed/id/6176493

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1 Pt 1
pubmed:dateCreated
1982-7-22
pubmed:abstractText
The first experimental production of Mallory bodies was reported by Denk et al. in 1975 in mice fed griseofulvin. We discovered a second chemical capable of producing Mallory bodies in the mouse liver in a manner similar to griseofulvin. Male Swiss albino mice were fed a powdered standard diet containing 2.5% of 3,5-diethoxycarbonyl-1,4-dihydrocollidine up to 95 days. The animals were killed at intervals and their livers were examined by light and electron microscopy. In general, the morphologic changes in the liver were similar to, but more marked than, those seen in griseofulvin-fed mice. Mallory bodies were first observed in the livers of mice killed at 40 days. In our previous experiment using griseofulvin, we first observed Mallory bodies in mice killed at 61 days. These observations suggest that 3,5-diethoxycarbonyl-1,4-dihydrocollidine may be more effective than griseofulvin in the production of Mallory bodies in mice.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0016-5085
pubmed:author
pubmed:issnType
Print
pubmed:volume
83
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
109-13
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Experimental production of Mallory bodies in mice by diet containing 3,5-diethoxycarbonyl-1,4-dihydrocollidine.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S.