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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1982-6-21
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pubmed:abstractText |
Previous studies have shown that influenza virus-immune cytotoxic T lymphocytes can recognize virus in conjunction with self HLA-A2 antigens. Nevertheless, the virus-infected target cells from one HLA-A2-positive male donor (designated M7) could not be lysed by the virus-immune cytotoxic lymphocytes from any HLA-A2-matched unrelated donors. Although extensive serological analyses showed no difference between the HLA-A2 antigens of donor M7 and other HLA-A2-positive donors, isoelectric focusing of the HLA-A2 molecule from donor M7 revealed a clear difference in the heavy polypeptide chains when compared with the HLA-A2 molecules of other donors. The present study demonstrates that the HLA-A2-restricted anti-H-Y cytotoxic T lymphocytes obtained from a female aplastic anaemia patient fail to lyse the male M7 target cells, whereas the HLA-A2-restricted anti-H-Y antibodies from the same patient react with the cells of donor M7. These results suggest that: (a) HLA-A2-restricted anti-H-Y antibodies can recognize self determinants on the HLA-A2 molecule that are distinct from those that are recognized by HLA-A2-restricted anti-H-Y cytotoxic T cells; and (b) HLA-restricted T and B cells may use different receptor repertoires for the recognition of foreign antigens such as H-Y.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6175722-1002160,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6175722-300847,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6175722-310866,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6175722-4442231,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6175722-501284,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6175722-593371,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6175722-6153199,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6175722-6157766,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6175722-6167549,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6175722-6967935,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6175722-78553,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6175722-78963
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0022-1007
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
155
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1567-72
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:6175722-Anemia, Aplastic,
pubmed-meshheading:6175722-Antibody Specificity,
pubmed-meshheading:6175722-Antilymphocyte Serum,
pubmed-meshheading:6175722-Cytotoxicity, Immunologic,
pubmed-meshheading:6175722-Epitopes,
pubmed-meshheading:6175722-Female,
pubmed-meshheading:6175722-H-Y Antigen,
pubmed-meshheading:6175722-HLA Antigens,
pubmed-meshheading:6175722-Humans,
pubmed-meshheading:6175722-Isoantibodies,
pubmed-meshheading:6175722-Male,
pubmed-meshheading:6175722-T-Lymphocytes
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pubmed:year |
1982
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pubmed:articleTitle |
Major histocompatibility complex-restricted H-Y-specific antibodies and cytotoxic T lymphocytes may recognize different self determinants.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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