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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
|
pubmed:dateCreated |
1982-5-27
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pubmed:abstractText |
Both natural killer cell- and macrophage-mediated spontaneous in vitro cytotoxicity for tumor targets is rapidly and strongly augmented by interferon. Macrophage-activating lymphokines considerably enhance macrophage-tumoricidal activity but did not affect natural killer cell-type cytotoxicity. Augmentation of cytolytic capacity by interferon and by macrophage-activating lymphokines is prevented by the tumor-promoting phorbol ester, 12-O-tetradecanoylphorbol-13-acetate. However, the classical antiviral activity and the specific binding of interferon to cell surface receptors remains unaffected by 12-O-tetradecanoylphorbol-13-acetate.
|
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Apr
|
pubmed:issn |
0008-5472
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:volume |
42
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
1468-72
|
pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:6174224-Animals,
pubmed-meshheading:6174224-Interferons,
pubmed-meshheading:6174224-Killer Cells, Natural,
pubmed-meshheading:6174224-Macrophages,
pubmed-meshheading:6174224-Mice,
pubmed-meshheading:6174224-Mice, Inbred Strains,
pubmed-meshheading:6174224-Neoplasms,
pubmed-meshheading:6174224-Phorbols,
pubmed-meshheading:6174224-Tetradecanoylphorbol Acetate,
pubmed-meshheading:6174224-Virus Replication
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pubmed:year |
1982
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pubmed:articleTitle |
Prevention of interferon-induced augmentation of cellular antitumor effector mechanisms by phorbol esters.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|