rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
1
|
pubmed:dateCreated |
1982-5-21
|
pubmed:abstractText |
The pharmacological actions of gamma-type endorphins show similarities to those of the neuroleptics. Two fragments of gamma-endorphin (beta-LPH 61-77) were therefore tested in patients with schizophrenic and schizo-affective psychoses who had shown an insufficient response to neuroleptics. The fragments were DT gamma E (beta-LPH 62-77) and DE gamma E (beta-LPH 66-77). Some of the patients studied responded favorably to this treatment. A number of criteria of differentiation between responders and nonresponders are discussed. The influence of DT gamma E on the central DA metabolism differs from that of the neuroleptics. It is therefore conceivable that gamma-type endorphins represent a different principle of action. The therapeutic efficacy of these compounds lends support to the hypothesis that disorders of central endorphin metabolism may play a role in the pathogenesis of psychoses of the schizophrenic type.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jan
|
pubmed:issn |
0006-3223
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:volume |
17
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
83-98
|
pubmed:dateRevised |
2007-11-15
|
pubmed:meshHeading |
pubmed-meshheading:6174158-Brain,
pubmed-meshheading:6174158-Clinical Trials as Topic,
pubmed-meshheading:6174158-Dopamine,
pubmed-meshheading:6174158-Double-Blind Method,
pubmed-meshheading:6174158-Endorphins,
pubmed-meshheading:6174158-Humans,
pubmed-meshheading:6174158-Peptide Fragments,
pubmed-meshheading:6174158-Psychotic Disorders,
pubmed-meshheading:6174158-Receptors, Dopamine,
pubmed-meshheading:6174158-Schizophrenia,
pubmed-meshheading:6174158-Schizophrenic Psychology,
pubmed-meshheading:6174158-beta-Endorphin,
pubmed-meshheading:6174158-gamma-Endorphin
|
pubmed:year |
1982
|
pubmed:articleTitle |
The treatment of schizophrenic psychoses with gamma-type endorphins.
|
pubmed:publicationType |
Journal Article,
Clinical Trial
|