Linked Life Data

6172838

Source:http://linkedlifedata.com/resource/pubmed/id/6172838

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
1982-3-13
pubmed:abstractText
In the present paper we report the effect of two methylxanthines (pentoxifylline and isobutylmethylxanthine) on the protein secretion in a model of exocrine gland (rat lacrimal gland). Both compounds are able to increase the protein release. This effect is dependent on the calcium concentration gradient between the extra- and intracellular media. The larger the difference, the greater the pentoxifylline or isobutylmethylxanthine effect. Moreover, pentoxifylline and isobutylmethylxanthine can potentiate the norepinephrine or isoproterenol effect by inhibiting phosphodiesterases (even in the absence of calcium). All these data suggest pentoxifylline and isobutylmethylxanthine can act on the cell functions in two ways: (a) by a calcium-dependent mechanism, either by increasing the influx of calcium into the cell or by mobilizing the pool of intracellular calcium; (b) by a mechanism independent of calcium and dependent on a system involving cyclic nucleotides. The first possibility seems to be very attractive for further investigations of the mechanism of action of pentoxifylline and especially when this drug is used to affect the cell motility or deformability controlled by calcium.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0085-591X
pubmed:author
pubmed:issnType
Print
pubmed:volume
156
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
309-12
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
A tentative explanation of the stimulatory effect of methylxanthines (pentoxifylline and isobutylmethylxanthine) on the secretory process in rat extraorbital lacrimal gland.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't