Linked Life Data

6172483

Source:http://linkedlifedata.com/resource/pubmed/id/6172483

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1982-3-13
pubmed:abstractText
By injecting cryptococcal antigen i.v. into CBA/J mice, we have simulated a level of antigenemia that is known to occur naturally in murine and human cryptococcosis. The cryptococcal antigen induced a population of lymph node (LN) cells that, upon adoptive transfer, could specifically suppress the delayed-type hypersensitivity (DTH) response to cryptococcal antigen and the splenic T lymphocytes responsible for in vitro inhibition of growth of Cryptococcus neoformans. The cryptococcal-antigen-induced suppressor cell could be detected in the LN as early as 5 days and was still in significant numbers 7 days after antigen injection. Suppressor cells were not found in the spleens of tolerized mice, nor could serum from these animals adoptively transfer suppression. The suppressor cells in this model were shown to be T lymphocytes, which exerted their effect on the afferent limb of the DTH response; therefore, they were similar to the Ts1 cell in the ABA-DTH, NP-DTH, and NP cutaneous sensitivity models and to the afferent suppressor cells in the DNFB contact sensitivity system. The percent suppression of the cryptococcal DTH response was dependent on the amount of antigen injected. Approximately, 35 micrograms of cryptococcal antigen per ml of serum was sufficient to induce significant suppression of the cell-mediated immune response.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0022-1767
pubmed:author
pubmed:issnType
Print
pubmed:volume
128
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
276-83
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1982
pubmed:articleTitle
Regulation of cell-mediated immunity in cryptococcosis. I. Induction of specific afferent T suppressor cells by cryptococcal antigen.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.