Linked Life Data

6172263

Source:http://linkedlifedata.com/resource/pubmed/id/6172263

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1982-3-22
pubmed:abstractText
The influence of different body temperatures on the epileptiform discharges induced in hippocampus by local microinjections of leu-enkephalin was studied in rats. In the absence of enkephalin, changes in body temperature by either cooling or heating induced epileptiform discharges that disappeared after temperature stabilization. The epileptiform episode induced by enkephalin microinjections was of longer duration at temperature below normal (29-30 degrees C). At body temperature above normal (39-40 degrees C) the epileptiform discharge was less intense and of shorter duration. In vitro testing led to parallel results: the destruction of enkephalin by the brain tissue was faster at higher temperatures. It is proposed that in conditions of hyperthermia enkephalin has a weaker activity due to acceleration of the activity of peptidases involved in its breakdown.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0013-4694
pubmed:author
pubmed:issnType
Print
pubmed:volume
52
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
640-6
pubmed:dateRevised
2008-9-9
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
Influence of body temperature on the epileptogenic effect of enkephalin microinjections into the hippocampus.
pubmed:publicationType
Journal Article