|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
1982-1-9
|
|
pubmed:abstractText |
The Ruthenium Red-insensitive efflux of Ca2+ from previously loaded rat liver mitochondria was studied as a function of the added Na+ concentration and ADP present. Stimulation of Ca2+ efflux is sigmoidally dependent on the Na+ concentration; maximal stimulation of efflux was observed with 12--15 mM-NaCl. Na+-stimulated Ca2+ efflux from liver mitochondria is about one-tenth that from cardiac mitochondria. No synergistic effect of K+ on the Na+-stimulated efflux was found. The alkali-metal cations other than Na+ did not stimulate efflux and did not prevent stimulation by Na+. In the absence of Na+, Ca2+ efflux was diminished by added ADP, but the Na+-stimulated efflux was made correspondingly greater as ADP concentration was increased to 16 microM. The Na+-stimulated Ca2+ efflux was inhibited by 70% by oligomycin and was not observed in the presence of antimycin. It is suggested that failure to observe Na+-stimulation of Ca2+ efflux from liver mitochondria by some investigators is attributable to a high basal efflux existing before addition of the Na+ salt.
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/6171263-1190784,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6171263-1194884,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6171263-23291,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6171263-41519,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6171263-4292886,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6171263-454375,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6171263-6162452,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6171263-7215682,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6171263-7371826,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6171263-7398884,
http://linkedlifedata.com/resource/pubmed/commentcorrection/6171263-923566
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Mar
|
|
pubmed:issn |
0264-6021
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
15
|
|
pubmed:volume |
194
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
925-9
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:6171263-Adenosine Diphosphate,
pubmed-meshheading:6171263-Animals,
pubmed-meshheading:6171263-Antimycin A,
pubmed-meshheading:6171263-Calcium,
pubmed-meshheading:6171263-Mitochondria, Liver,
pubmed-meshheading:6171263-Rats,
pubmed-meshheading:6171263-Ruthenium Red,
pubmed-meshheading:6171263-Sodium,
pubmed-meshheading:6171263-Stimulation, Chemical
|
|
pubmed:year |
1981
|
|
pubmed:articleTitle |
Stimulation of calcium-ion efflux from liver mitochondria by sodium ions and its response to ADP and energy state.
|
|
pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
|
