Linked Life Data

6171153

Source:http://linkedlifedata.com/resource/pubmed/id/6171153

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1982-1-20
pubmed:abstractText
Two hundred and twenty-five Polynesians were selected from a larger study population for the evaluation of potential genetic influences on the susceptibility to bancroftian filariasis. Analysis showed that there was significantly familial clustering of patients with filariasis and that this clustering was most compatible with genetic transmission of disease susceptibility. The data best fit a model in which the hypothetical gene for filariasis was recessive with a frequency of 0.82 +/- 0.15 in the population and a penetrance of 0.62 +/- 0.14. The alternative hypothesis that susceptibility was environmentally (i.e., not genetically) determined was also compatible with the data but was estimated to be 1.9 times less likely to account for the observed findings than the genetic hypothesis. Extensive evaluation of HLA-A and -B locus specificities failed to detect significant linkage either between particular antigen specificities and the clinical manifestations of filariasis or between individual haplotypes (indicated by HLA markers in studies of large families) and the predisposition to filarial infection or disease.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0001-706X
pubmed:author
pubmed:issnType
Print
pubmed:volume
38
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
205-16
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
Familial predisposition to filarial infection--not linked to HLA-A or-B locus specificities.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.