Linked Life Data

6170649

Source:http://linkedlifedata.com/resource/pubmed/id/6170649

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1982-1-28
pubmed:abstractText
A temperature sensitive mutant of BHK21, tsBN2, showed a premature chromosome condensation (PCC) upon the temperature shift of 40.5 degrees, even in the absence of DNA replication. The induction of PCC requires new protein synthesis, but not necessarily new RNA synthesis. Our data suggested that the messenger RNA for chromosome condensation starts to be transcribed at the beginning of S phase. At the permissive temperature (33.5 degrees), the messenger RNA for chromosome condensation translated with a very slow rate during S phase and rapidly in G2-M phase. At the nonpermissive temperature (40.5 degrees), however, those messenger RNAs were translated anytime, so that various figures of PCC appeared depending on the cell cycle. On the way of PCC induction, ribosomal RNA synthesis was inhibited at first, as expected from mitosis. Our data suggested that the synthesis of protein(s) for chromosome condensation was regulated by the post-transcriptional mechanism, in which tsBN2 might be defective, especially at the translational level.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0021-9541
pubmed:author
pubmed:issnType
Print
pubmed:volume
109
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
299-308
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
The synthesis of protein(s) for chromosome condensation may be regulated by a post-transcriptional mechanism.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't