Linked Life Data

6170567

Source:http://linkedlifedata.com/resource/pubmed/id/6170567

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
10
pubmed:dateCreated
1982-1-20
pubmed:abstractText
The bacterial etiology of Whipple's disease is generally accepted. However, the exact identity of the "Whipple bug" has remained elusive. Indeed, the isolation of several types of bacteria from different patients with Whipple's disease has caused some to speculate that Whipple's disease may have polymicrobial etiology. Our light and electron microscopic studies document the presence of bacilliform organisms lying free in the lamina propria of the duodenal mucosa. Intact and partially degraded bacterial organisms were seen in the phagosomes of macrophages. Indirect immunofluorescence studies demonstrated the presence of multiple bacterial antigens in the lamina propria as well as the macrophage granules. This profile of antigens is similar to the profile demonstrated in four other patients in two previous studies. The occurrence of similar profiles of bacterial antigens in the tissues of different patients with Whipple's disease suggests a single microorganism in the etiology of Whipple's disease. Because of the overlapping features of muciphages and Whipple's cells in the rectal biopsy material, the superiority and reliability of proximal small intestinal biopsy in preference to rectal biopsy are re-emphasized.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0046-8177
pubmed:author
pubmed:issnType
Print
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
930-6
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
Whipple's disease: morphologic and immunofluorescence characterization of bacterial antigens.
pubmed:publicationType
Journal Article, Case Reports