|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0004609,
umls-concept:C0020663,
umls-concept:C0027882,
umls-concept:C0038585,
umls-concept:C0183683,
umls-concept:C0332206,
umls-concept:C0344211,
umls-concept:C0441472,
umls-concept:C0999699,
umls-concept:C1171411,
umls-concept:C1317973,
umls-concept:C1521721,
umls-concept:C1533691
|
|
pubmed:issue |
7
|
|
pubmed:dateCreated |
1981-11-18
|
|
pubmed:abstractText |
Effects of substance P on neurons of the guinea-pig hypothalamus in vitro and antagonism between substance P and baclofen were investigated. Substance P increased the firing rate of neurons in the medium containing 0 mM Ca2+ and 12 mM Mg2+. The excitatory action of substance P was antagonized by a low dose of baclofen whereas that of acetylcholine was not antagonized even by much higher doses of baclofen.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jul
|
|
pubmed:issn |
0014-4754
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
15
|
|
pubmed:volume |
37
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
759-61
|
|
pubmed:dateRevised |
2006-11-15
|
|
pubmed:meshHeading |
pubmed-meshheading:6168489-Acetylcholine,
pubmed-meshheading:6168489-Action Potentials,
pubmed-meshheading:6168489-Animals,
pubmed-meshheading:6168489-Baclofen,
pubmed-meshheading:6168489-Dose-Response Relationship, Drug,
pubmed-meshheading:6168489-Female,
pubmed-meshheading:6168489-Guinea Pigs,
pubmed-meshheading:6168489-Hypothalamus,
pubmed-meshheading:6168489-Male,
pubmed-meshheading:6168489-Neurons,
pubmed-meshheading:6168489-Substance P,
pubmed-meshheading:6168489-Synapses,
pubmed-meshheading:6168489-gamma-Aminobutyric Acid
|
|
pubmed:year |
1981
|
|
pubmed:articleTitle |
Further support for the postsynaptic action of substance P and its blockade with baclofen in neurons of the guinea-pig hypothalamus in vitro.
|
|
pubmed:publicationType |
Journal Article,
In Vitro
|
