Linked Life Data

6167480

Source:http://linkedlifedata.com/resource/pubmed/id/6167480

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
9
pubmed:dateCreated
1981-10-25
pubmed:abstractText
Exposure of isolated rat pancreatic islets to 1 mM 3-isobutyl-1-methyl-xanthine (IBMX) resulted in a 5.7-fold increase in the rate of insulin release. After a 30-min rest period under basal conditions, reexposure of the islets to 1 mM IBMX resulted in an enhanced rate of release when compared with either a timed control -islets simultaneously exposed to IBMX for the first time-or with the first priming response to IBMX. The possibility of a continuous priming effect was suggested by the gradually rising rate of insulin release during exposure to IBMX. It is concluded that islets have a memory for IBMX exposure that results in increased responsiveness to subsequent stimulation by IBMX.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0012-1797
pubmed:author
pubmed:issnType
Print
pubmed:volume
30
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
754-6
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1981
pubmed:articleTitle
Insulin release. Demonstration of a priming effect of 3-isobutyl-1-methyl-xanthine (IBMX) on islets of Langerhans.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't